Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX
نویسندگان
چکیده
منابع مشابه
Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.
The BCL-2 gene family regulates the susceptibility to apoptotic cell death in many cell types during embryonic development and normal tissue homeostasis. Deregulated expression of anti-apoptotic BCL-2 can be a primary aberration that promotes malignancy and also confers resistance to chemotherapeutic agents. Recently, studies of Bax-deficient mice have indicated that the pro-apoptotic BAX molec...
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ژورنال
عنوان ژورنال: Blood
سال: 1998
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v91.8.2991.2991_2991_2997